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1.
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.
Proc Natl Acad Sci U S A;
118(29)2021 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34210738
2.
Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus.
Microbiol Spectr;
12(4): e0337223, 2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38466127
3.
Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment.
mBio;
15(2): e0287823, 2024 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38126789
4.
Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV).
Eur J Med Chem;
254: 115376, 2023 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37080108
5.
Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies.
ACS Pharmacol Transl Sci;
6(1): 181-194, 2023 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36654747
6.
Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease.
J Med Chem;
65(11): 7818-7832, 2022 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35638577
7.
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease.
J Med Chem;
64(14): 10047-10058, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34213885
8.
Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies.
J Med Chem;
64(24): 17846-17865, 2021 12 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34865476
9.
Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease.
J Med Chem;
63(20): 11945-11963, 2020 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32945669
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